Many U.S. colleges and universities are anxiously wondering if newly admitted Chinese students will accept their admission offers and return to American campuses in fall 2021. Needing to balance a host of issues, will Chinese students decide to remain at home or study in a different host country? This IIENetwork Briefing paper assesses the current situation, explores possible outcomes for fall 2021 enrollments from China’s mainland and Hong Kong, and presents some ways that U.S. campuses are responding to these recruiting challenges during a changing political and health environment in both the host and home countries.